Dennis Lal

I am a “Research Scientist” at the Stanley Center (and Group Leader at the Cologne Center for Genomics).

Why did the patient develop this disease?” “Will the patient respond to this medication?” “Can we predict the disease prognosis?” “What is the underlying mechanism?”

My long-term research interests involve the development of a comprehensive understanding of how alterations in the genome contribute to brain disorders. My academic training and research experiences have provided me with an excellent background in multiple disciplines including molecular biology, genetics, and bioinformatics as well as a comprehensive understanding of the clinical and neurological presentation of neuropediatric disorders. Overall, the main focus of the group that I lead is the discovery, evaluation, and translation of genetic variants into clinical care. Specifically, we aim to develop computational methods which integrate large genetic, clinical, and biological data sets to improve the prediction of genetic variant effects on patient outcomes – paving the way for personalized medicine.