Bram is a computational scientist in the Karczewski Lab at the Broad Institute. He received his PhD in operations research from Tilburg University. He was an assistant professor at VU Amsterdam where he created and gave courses on big data and on convex optimization. He developed Nymph, the fastest exact inverse planning algorithm for radiation therapy, which is currently used by Massachusetts General Hospital. Previously he worked in the Fishell lab on, i.a., discovering enhancers.