Bloom, Jonathan

Jonathan Bloom, PhD

Jon Bloom is a mathematician, engineer, and co-founder of the Hail project ( at the Broad Institute, building an open-source framework for scalable genomic analysis. He also co-founded and directs the Models, Inference & Algorithms Initiative (, bridging computational biology, mathematical theory and machine learning. Prior to joining the Broad, he did research in geometry and algebraic topology as a Moore Instructor and NSF Postdoctoral Fellow in Mathematics at the Massachusetts Institute of Technology. While there, he re-architected the department’s course 18.05 on probability and statistics for life scientists, now among the most popular offerings on MIT OpenCourseWare. He received his B.A. from Harvard University and Ph.D. from Columbia University in Mathematics.


Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki MI, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman CM, Neale BM
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.
Nat Neurosci. 2016;19(12):1563-1565 - PMID: 27694993 - PMCID: PMC5127781