Jackie Goldstein is an Associate Computational Biologist at ATGU and the Broad Institute of MIT and Harvard. Her primary research interest is the genetics of severe adverse drug reactions including clozapine-induced agranulocytosis and drug-induced liver injury. She has also worked with the Genetic Analysis Platform (now the Genomics Platform) at the Broad to develop a rare variant caller for genotyping arrays and contributed her expertise to a number of Exome Chip projects.
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.
Analysis of protein-coding genetic variation in 60,706 humans.
Nature. 2016;536(7616):285-91 - PMID: 27535533
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nat Commun. 2014;5:4757 - PMID: 25187353
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.