Hailiang Huang is an Instructor in the Analytic and Translational Genetics Unit at Massachusetts General Hospital and an Associated Scientist of the Broad Institute of MIT and Harvard. He is also an instructor in the Department of Medicine at Harvard Medical School.
Hailiang’s research focuses on the genetics of complex disorders, especially autoimmune and psychiatric disorders. He is interested in developing new statistical and analytical methods, and use them to pinpoint and understand the genetic factors driving human complex disorders. His studies usually use large-scale omics data from various consortia and public available sources such as UK Biobank, NIH Roadmap, and GTEx.
Hailiang developed GWiS, a gene-based association test that has been used in many consortia to find genes associated with human complex disorders (Huang et al., PLoS Genetics, 2011). He is a member of the International Inflammatory Bowel Diseases Genetics Consortium (IIBDGC) and has co-led its recent fine-mapping effort to resolve known genetic associations to variants with high causal probabilities (Huang et al., Nature, 2017). He is also leading a workgroup in the Psychiatric Genomics Consortium (PGC) to build a large-scale Asian schizophrenia cohort and use this cohort to understand the genetic architecture of schizophrenia in the Asian populations. Hailiang’s other research interests include developing methods for testing rare variants with population stratification, investigating the connection between tissue-specific gene regulation and non-coding genetic associations, and understanding the genetic mechanisms underlying the spontaneous clearance of the hepatitis C virus.
Hailiang received cross-disciplinary training combining engineering, genetics and medicine. He earned his Ph.D. from the Department of Biomedical Engineering at the Johns Hopkins School of Medicine, supervised by Dr. Joel Bader. He completed his postdoctoral training with Dr. Mark Daly at MGH and the Broad Institute.
Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway.
J Orthop Surg Res. 2017;12(1):110 - PMID: 28701229
Effects of Lactobacillus rhamnosus GG on the maturation and differentiation of dendritic cells in rotavirus-infected mice.
Benef Microbes. 2017;:1-12 - PMID: 28670908
Integrative Genetic and Epigenetic Analysis Uncovers Regulatory Mechanisms of Autoimmune Disease.
Am J Hum Genet. 2017;101(1):75-86 - PMID: 28686857
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
Nat Genet. 2016;48(10):1296 - PMID: 27681292
Characterization of candidate genes in inflammatory bowel disease-associated risk loci.
JCI Insight. 2016;1(13):e87899 - PMID: 27668286
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.
Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.
Immunity. 2015;43(4):715-726 - PMID: 26488816
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
Nat Commun. 2015;6:5966 - PMID: 25608926
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Complex host genetics influence the microbiome in inflammatory bowel disease.
Genome Med. 2014;6(12):107 - PMID: 25587358
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nat Commun. 2014;5:4757 - PMID: 25187353
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.