Chen, Chia-Yen

Chia-Yen Chen, ScD

Chia-Yen Chen, Sc.D. is a postdoctoral research fellow at the Analytic and Translational Genetics Unit (ATGU) and the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) at Massachusetts General Hospital. Dr. Chen is also affiliated with the Broad institute and the Harvard School of Public Health. His mentors are Jordan Smoller, M.D., Sc.D., and Benjamin Neale, Ph.D.

Dr. Chen’s research interests lie in genetic epidemiology and population genetics. Dr. Chen has been developing new methods for genetic risk prediction and applying these methods to real data analyses. These methods include improved polygenic prediction models by leveraging genetic ancestry information, genetic risk prediction models based on pleiotropic effects, and prediction models using genetic factors, environmental factors, family history and interactions between risk factors. He also developed methods for ancestry inference with better efficiency than current methods. His recent research focuses on applying these methods in combination with other existing methods to understand the genetic architecture of psychiatric disorders, including post-traumatic stress disorder (PTSD), bipolar disorder, and electroencephalography (EEG) phenotypes among schizophrenia and bipolar disorder patients.

Dr. Chen earned a BSc in Life Science in 2004 and a MSc in Epidemiology in 2006 from National Taiwan University. He earned a Sc.M. in Biostatistics in 2012 and a Sc.D. in Epidemiology in 2013 from the Harvard School of Public Health. His doctoral advisor was Alkes L. Price, Ph.D.


Ge T, Chen CY, Neale BM, Sabuncu MR, Smoller JW
Phenome-wide heritability analysis of the UK Biobank.
PLoS Genet. 2017;13(4):e1006711 - PMID: 28388634
Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW, Army Study to Assess Risk and Resilience in Servicemembers (STARRS) Collaborators
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.
JAMA Psychiatry. 2016;:ePub - PMID: 27167565